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Prevention

Epidemiology

HCV (BF) Viral hepatitis are neglected diseases in resources limited settings, although their public health impact is enormous. However, cheap multiple infections screening strategies using DBS are available but never tested with this purpose. After a description of the epidemiology of HBV/HCV infections in Burkina using DBS collected during the 2010 DHS, we will assess several DBS-based screening strategy.

 

Hard-to-reach population

  • PWID (DRIVE) This project was presented previously. Over the next 5 years, we aim at implementing an ambitious multidisciplinary research platform in Hai Phong to address research questions relevant to the control of chronic infections among PWID. The core activity of this platform will be to follow a cohort of PWID, including the most at risk and the most difficult to reach, on which various projects will be nested from fundamental research to the evaluation of interventions. Strongly supported by the local and national Health authorities, and open to the local scientific community, this cohort will have a national and a regional (South-East Asia) relevance.
  • Female sex workers in Africa
    Our group has been leading for 10 years, until 2010, interventional studies to elaborate the best strategies to improve HIV prevention and the cascade of care among FSW in Burkina Faso. We defined an optimal intervention in the local context, based on a peer-led dedicated clinic which integrates peer-led prevention and care. Since then, the 2 clinics in Burkina Faso (Ouagadougou and Bobo-Dioulasso) have continued their activities, and the research findings is now been implementing as a national program.
    We collaborate with a Canadian project led by Prof. Michel Alary in Quebec, which will extend the domains of intervention to other topics such as cervical cancer screening, drug use or violence.
  • HIV: PROMISE-EPI:
    Despite the recommendation of universal ART to HIV-infected pregnant or lactating women, each year approximately 150,000 to 200,000 children acquire HIV, mainly by breastfeeding.
    The PROMISE-EPI project is based on the knowledge accumulated on the pathogenesis of HIV transmission by breastfeeding and on the known obstacles to PMTCT implementation identified during many years of operational research on PMTCT in African settings. The project aims to eliminate this residual HIV transmission by breastfeeding by implementing and testing an innovative rescue strategy consisting of identifying women at risk of transmission at the first EPI visit and protecting their babies by infant PrEP during the time of their HIV exposure by breastfeeding. This phase IIb/III trial will be conducted in Burkina Faso and in Zambia, with support from the Thrasher Research Fund and EDCTP.

Nicolas Nagot

Scientific supervisor

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