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Prevention of the transmission of infectious agents (vertical , sexual, transfusional transmissions, IV drugs & other parenteral ways)

ID-Blood – A lateral flow test for rapid and visual blood group genotyping

Prevention of infectious & immunohemotological risks for improving blood safety

The haemagglutination is the standard method for the determination of red blood cell phenotype. However, this serological technique has some limitations, especially in certain clinical situations (polytransfused patients, presence of autoantibodies…) where the patient’s phenotype cannot be determined. In these cases, the determination of the genotype by molecular biology, for the clinically relevant antigens, could overcome these difficulties by providing patient’s phenotype predicted from the genotype, and to prevent the risk of red blood cell alloimmunization.
To overcome these limitations, we developed a rapid and visual test allowing simultaneous determination of the genotype of the six clinically relevant blood antigens (JK1, JK2, FY1, FY2, MNS3, MNS4) for the management of patient requiring transfusion, in order to predict the extended-antigen phenotype. Our patented technology (PCT/FR2016052272) is based on the co-amplification of multiple regions of gDNA and the use of a lateral-flow test for visual reading of results with naked-eye.

Decontamination procedures

A compléter par Daisy

Chantal Fournier

Scientific supervisor

Chantal FOURNIER-WIRTH obtained a PhD Degree in Life Sciences, Biochemistry and Molecular Biology at the University of Montpellier (France) in 1999. She started her career as a researcher at the EFS (Etablissement Français du Sang) in the team directed by Dr Joliette Coste in Montpellier. The team has merged with clinicians in 2015 in a mixed research unit dedicated to the pathogenesis and control of chronic infections. She is now involved in the development and the coordination of multidisciplinary projects on diagnostic innovations.

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Edouard Tuaillon

Scientific supervisor

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