menu search download flag tag book folder external-link phone envelope angle-left angle-right angle-up angle-down close notifications

Arboviruses

Arboviruses are mainly transmitted to humans through the bites of several species of Aedes mosquitoes. In the context of similar clinical signs, the differential diagnosis of arboviruses is essential to discriminate the causative agent for the effective management of patient, the clinical care and the epidemiological surveillance. The african continent should not be isolated from this surveillance; Aedes aegypti and Aedes albopictus circulate in sub-Saharan Africa, and more than 900 million people are potentially exposed to mosquito bites as recently reported (Meda N. et al , Lancet 2016). In view of the new risks of intercontinental dissemination of mosquitoes and of imported cases from travelers, it is essential to develop new strategies for the prevention and control of epidemics. Furthermore, for the first time, an arbovirus, ZIKV, is capable of sexual transmission and is associated with microcephalia and severe neurological damage in newborns. The screening of blood donors and returning travelers from active transmission areas have also highlighted the importance of multiplex diagnostic approaches for the simultaneous analysis of various pathogens.

The UMR1058 is involved in the clinical testing of arboviruses and in the development of flexible diagnostic approaches that are a key challenge to face the continuing emergence of arboviruses, belonging to flavivirus (dengue, West-Nile, Yellow fever, Zika, Usutu …) or alphavirus genera (chikungunya virus). An innovative multiplex diagnostic approach based on the generic amplification of the viral genomes and their identification after hybridization on original polythiolated probes is currently in development.

Chantal Fournier

Scientific supervisor

Chantal FOURNIER-WIRTH obtained a PhD Degree in Life Sciences, Biochemistry and Molecular Biology at the University of Montpellier (France) in 1999. She started her career as a researcher at the EFS (Etablissement Français du Sang) in the team directed by Dr Joliette Coste in Montpellier. The team has merged with clinicians in 2015 in a mixed research unit dedicated to the pathogenesis and control of chronic infections. She is now involved in the development and the coordination of multidisciplinary projects on diagnostic innovations.

Link 1 | Email

Edouard Tuaillon

Scientific supervisor

Aenean commodo pharetra lectus eget tincidunt. Quisque porta turpis sed nibh lobortis blandit. Maecenas nisl mauris, elementum sed ultrices id, pharetra in velit. Quisque nulla erat, sodales at condimentum in, pulvinar condimentum urna. Ut massa enim, aliquam id viverra sit amet, bibendum sed orci. Proin tincidunt ultricies lectus, sed fermentum lorem consectetur vel. Phasellus ut enim dui. Fusce tincidunt vulputate vestibulum. Nunc nec justo et odio dictum efficitur. Donec velit ante, maximus eget purus ut, molestie ornare lorem. Praesent varius scelerisque erat sed bibendum.

Link 1 | Email