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Pathogenesis and new approaches to prevention and care

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Nicolas Nagot

Diagnostic and Therapeutic Innovations

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Chantal Fournier
Edouard Tuaillon


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Jean-Pierre MOLES


The principle of our research unit is to harbor under the same roof the different sectors of research contributing to the common goal of improving care and prevention of chronic infections: cognitive (basic science), translational and clinical research. A multidisciplinary approach and organization is prioritized in order to benefit as much as possible from synergy inside and outside the unit and to maximize the opportunities to benefit from support of national, European and international funds in integrative research projects.

Strategic and scientific objectives

  • To create an integrated research structure dedicated to chronic infections
  • To ensure a multidisciplinary continuum between cognitive, translational and clinical research, with a strong connection with the Montpellier University Teaching Hospital (CHRU).
  • To Study host-pathogens interactions at the molecular, cellular and host levels (pathogens such as HIV, HTLV-I, HPV, HCV, HBV, HSV, dengue, arboviruses, endogenous retroviruses, mycobacteria, etc.).
  • To establish the place of chronic infections and their control in the national and international Public Health stakes.
  • To include pathogenesis and control of chronic infections in national and international cognitive and interventional programs on chronic diseases and ageing.
  • To facilitate innovation (drug discoveries, diagnostic tools) and industrial partnerships in close vicinity with open platforms (CEMIPAI, BioCampus, …).and private companies
  • To stimulate international research partnerships on chronic infections, in particular with low and middle income countries (LMIC).


Benefiting from the firm foundation of a university hospital, in which clinical research is in one of our know-how, we believe in the added value given by the support of fundamental or « mechanistic » explanatory research to clinical research. These two aspects of health research, clinical and basic sciences, act in synergy and mobilize knowledge and new concepts in their translations into public health interventions. The basic philosophy of our scientific commitment in translational research remains unchanged: the implementation of innovative research in fields of chronic infections of public health interest and the simple pleasure of working together.


UMR 1058 was created in January 2011 after the merging a university research team (EA4205) dedicated to research on HIV pathogenesis, transmission and prevention with a group from the Molecular Dermatology Unit of the University Institute of Clinical Research (IURC) having a sound experience in research on viruses with mucocutaneous tropism. In 2015, our field of expertise widened still when we teamed up with the EFS (French Blood Services) Transdiag team dedicated to innovation in diagnosis of infectious diseases.

Originally composed of 28 people it has been progressively enriched by new personnel and now counts up to around 70 members in total ((including INSERM, University of Montpellier, and EFS staff members).


Our activities are located on 2 sites:

  • INSERM delegation where most activities are located in a square meters laboratory;
  • EFS ZRR campus, where are conducted studies on prion and other blood borne agents.

Scientific partners

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